rs2418087
This is a intron variant variant in the STYK1 gene.
▶Research that mentions this SNP (1)
▶Insight in glioma susceptibility through an analysis of 6p22.3, 12p13.33-12.1, 17q22-23.2 and 18q23 SNP genotypes in familial and non-familial gliomaAssociationN=2,175Yanhong Liu et al.(2012)· Human Genetics
This family-based association study identified genetic variants associated with familial glioma by analyzing 5,122 SNPs in four chromosomal regions in 88 glioma cases with family history versus 1,100 without (discovery study) and validated findings in 84 familial and 903 sporadic cases. The strongest associations in the combined analysis were at 12p13.33-12.1 (PRMT8 rs17780102 OR=2.13, SOX5 rs7305773 OR=3.53, STYK1 rs2418087 OR=1.88) and 17q12-21.32 (SPOP rs6504618 OR=2.01, p=0.0006), with significant dose-effect relationship across four risk variants.
About STYK1
Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]
View all STYK1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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