rs2426295
This is a intron variant variant in the NFATC2 gene.
▶Research that mentions this SNP (1)
▶Polymorphisms of nucleotide factor of activated T cells cytoplasmic 2 and 4 and the risk of acute rejection following kidney transplantationAssociationN=200Zijie Wang et al.(2018)· World Journal of Urology
A retrospective case-control study of 200 kidney transplant recipients (69 with acute rejection, 131 stable) using next-generation sequencing to identify SNPs in NFATC2 and NFATC4 genes. Among 71 identified SNPs, rs2426295 in NFATC2 showed significant association with acute rejection in the heterozygous comparison model (AA vs. AC: OR = 0.43, 95% CI = 0.19–0.98, P = 0.045), with AA genotype carriers having increased susceptibility to post-transplant rejection.
About NFATC2
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]
View all NFATC2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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