rs242941
This variant is located in the CRHR1 gene.
▶Research that mentions this SNP (2)
▶Association of CRHR1 and CRHR2 with major depressive disorder and panic disorder in a Japanese populationAssociationN=638Yoshinobu Ishitobi et al.(2012)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
This Japanese case-control study examined 12 SNPs in CRHR1 and CRHR2 genes in 173 major depressive disorder (MDD) patients, 180 panic disorder (PD) patients, and 285 healthy controls. SNP rs110402 in CRHR1 showed association with MDD (p=0.001, OR=1.81), as did rs242924 in CRHR1 for both MDD (p=0.013) and PD (p=0.022, OR=1.55). SNP rs3779250 in CRHR2 showed strong association with MDD (p=1.75e-11, OR=2.83). Haplotype analyses identified T-A-T-G-G and T-A haplotypes in CRHR1 associated with MDD, and C-C haplotype in CRHR2 associated with PD.
▶Risk and resilience: Genetic and environmental influences on development of the stress responseReviewCharles F. Gillespie et al.(2009)· Depression and Anxiety
This review examines gene-environment interactions in stress-related psychiatric disorders, focusing on CRHR1 and FKBP5 genes. Authors report that CRHR1 polymorphisms (rs7209436, rs110402, rs242924) interact with childhood abuse to predict adult depression, while FKBP5 variants (rs3800373, rs9296158) interact with child abuse to predict adult PTSD symptoms. The paper integrates human genetic association findings with preclinical research on amygdala-HPA axis development, proposing a model where gene-environment interactions during developmental critical periods mediate stress resilience and psychiatric vulnerability.
About CRHR1
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Naturally-occurring readthrough transcription between this gene and upstream GeneID:147081 results in transcripts that encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Aug 2016]
View all CRHR1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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