rs2429511

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

platelet component distribution width

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.02
p 3.0e-19
N 394,642
Large GWAS
European
Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)
Allele C
OR 0.02
p 1.0e-13
N 408,112
Large GWAS
European

adiponectin measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.03
p 9.0e-12
N 47,745
Large GWAS
European
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Research that mentions this SNP (1)

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Combining fMRI and SNP data to investigate connections between brain function and genetics using parallel ICA
MethodsN=63Jingyu Liu et al.(2009)· Human Brain Mapping

This paper presents parallel Independent Component Analysis (ICA), a novel multivariate method for jointly analyzing functional MRI and SNP data to identify connections between brain function and genetic variation. Applied to 63 participants (20 schizophrenia patients, 43 controls), the method extracted linked components from 367 SNPs and fMRI data, identifying a genetic component containing SNPs in genes such as DISC1 (rs821616), ADRA2A (rs2429511), and CHRNA7 (rs3087454) that correlated with fMRI-derived brain networks involved in the auditory oddball task.

Traits studied:Auditory oddball taskBrain activation patternsSchizophrenia
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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