rs2442631
This is a intron variant variant in the ANGPT2 gene.
▶Research that mentions this SNP (1)
▶Genetic variations in angiopoietin and pericyte pathways and clinical outcome in patients with resected colorectal liver metastasesAssociationN=149Stefan Stremitzer et al.(2015)· Cancer
This candidate gene study investigated 9 genes in angiopoietin and pericyte pathways in 149 patients with colorectal liver metastases treated with neoadjuvant/adjuvant fluoropyrimidine-based chemotherapy plus bevacizumab and liver resection. Key findings: RALBP1 rs329007 associated with shorter recurrence-free survival (HR 1.99, p=0.002) and higher radiological response (94% vs 78%); PDGFB rs1800818 associated with worse 3-year overall survival (53% vs 78%, p=0.048); ANGPT2 rs2916702 and rs2442631 predicted probability of cure.
About ANGPT2
This gene belongs to the angiopoietin family of growth factors. The protein encoded by this gene is an antagonist of angiopoietin 1, and both angiopoietin 1 and angiopoietin 2 are ligands for the endothelial TEK receptor tyrosine kinase. Angiopoietin 2 is upregulated in multiple inflammatory diseases and is implicated in the direct control of inflammation-related signaling pathways. The encoded protein affects angiogenesis during embryogenesis and tumorigenesis, disrupts the vascular remodeling ability of angiopoietin 1, and may induce endothelial cell apoptosis. This gene serves a prognostic biomarker for acute respiratory distress syndrome. [provided by RefSeq, Aug 2020]
View all ANGPT2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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