rs2451321

This is a intron variant variant in the ZNF664-RFLNA gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

type 2 diabetes mellitus

Elashi AA et al. “Genome-wide association study and trans-ethnic meta-analysis identify novel susceptibility loci for type 2 diabetes mellitus.” Bmc Medical Genomics 17(1):115 (2024)

Allele C

OR 0.03

p 5.0e-11

N 6,710,881

Meta-analysisLarge GWAS

multi-ancestry

Mahajan A et al. “Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.” Nature Genetics 54(5):560-572 (2022)

Allele C

OR 1.03

p 8.0e-10

N 492,192

Large GWAS

multi-ancestry

About ZNF664-RFLNA

This locus represents naturally occurring read-through transcription between the neighboring zinc finger protein 664 (Gene ID: 144348) and refilin A (Gene ID: 144347) genes on chromosome 12. The read-through transcript produces a protein that shares sequence identity with the downstream refilin A gene product. [provided by RefSeq, Dec 2016]

View all ZNF664-RFLNA variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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