rs2494114

This is a downstream gene variant variant in the IPO9 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body mass index

Hoffmann TJ et al. “A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.” Genetics 210(2):499-515 (2018)

Allele C

OR —

β 0.027

p 3.0e-20

N 334,487

Large GWAS

multi-ancestry

Abnormality of the skeletal system

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.01

p 7.0e-18

N 394,642

Large GWAS

European

About IPO9

Enables histone binding activity; histone chaperone activity; and nuclear import signal receptor activity. Involved in proteasome localization and protein import into nucleus. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

View all IPO9 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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