rs2504093

This is a regulatory region variant variant in the DAAM2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

type 2 diabetes mellitus

Suzuki K et al. “Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.” Nature 627(8003):347-357 (2024)

Allele C

OR —

p 4.0e-10

N 2,535,601

Large GWAS

multi-ancestry

About DAAM2

Predicted to enable actin binding activity and small GTPase binding activity. Involved in several processes, including podocyte cell migration; regulation of actin filament polymerization; and regulation of filopodium assembly. Located in extracellular exosome. Implicated in familial nephrotic syndrome. [provided by Alliance of Genome Resources, Jul 2025]

View all DAAM2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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