rs2505083
This variant is located in the JCAD gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
myocardial infarction
Hartiala JA et al. “Genome-wide analysis identifies novel susceptibility loci for myocardial infarction.” European Heart Journal 42(9):919-933 (2021)
Allele C
OR 1.05
p 7.0e-10
N 639,221
Large GWAS
multi-ancestry
Nikpay M et al. “A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.” Nature Genetics 47(10):1121-1130 (2015)
Allele C
OR 1.06
p 7.0e-9
N 166,459
Meta-analysisLarge GWAS
multi-ancestry
heart failure
Jordà P et al. “Genetic analyses across cardiovascular traits: leveraging genetic correlations to empower locus discovery and prediction in common cardiovascular diseases.” Npj Genomic Medicine 10(1):65 (2025)
Allele C
OR 5.54
p 3.0e-8
N 358,418
Large GWAS
European
coronary artery disease
“A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.” Nature Genetics 43(4):339-44 (2011)
Allele C
OR 1.07
p 4.0e-8
N 30,482
Large GWAS
multi-ancestry
About JCAD
This gene encodes an endothelial cell-to-cell junction protein. Naturally occurring mutations in this gene are associated with coronary artery disease, late onset alzheimer disease, and emphysema distribution. [provided by RefSeq, Mar 2017]
View all JCAD variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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