rs2540951

This is a regulatory region variant variant in the LINC02576 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

type 2 diabetes mellitus

Huerta-Chagoya A et al. “Rare variant analyses in 51,256 type 2 diabetes cases and 370,487 controls reveal the pathogenicity spectrum of monogenic diabetes genes.” Nature Genetics 56(11):2370-2379 (2024)

Allele G

OR 0.06

p 4.0e-15

N 421,743

Large GWAS

multi-ancestry

atrial fibrillation

Hong M et al. “Ethnic similarities in genetic polymorphisms associated with atrial fibrillation: Far East Asian vs European populations.” European Journal of Clinical Investigation 51(9):e13584 (2021)

Allele A

OR 1.18

p 5.0e-14

N 42,585

Large GWAS

East Asian

apolipoprotein A 1 measurement

Richardson TG et al. “Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis.” Plos Medicine 17(3):e1003062 (2020)

Allele A

OR 0.01

p 2.0e-9

N 393,193

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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