rs2545774

This variant is located in the RAB4B gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

venous thromboembolism

Thibord F et al. “Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors.” Circulation 146(16):1225-1242 (2022)

Allele T

OR 0.04

p 7.0e-9

N 1,508,386

Large GWAS

multi-ancestry

About RAB4B

Enables GTPase activity. Involved in D-glucose import; early endosome to Golgi transport; and endosomal vesicle fusion. Located in insulin-responsive compartment; perinuclear region of cytoplasm; and recycling endosome. Is active in early endosome membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all RAB4B variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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