rs2545797
This is a downstream gene variant variant in the GRK6 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
intelligence
Coleman JRI et al. “Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals.” Molecular Psychiatry 24(2):182-197 (2019)
Allele T
OR 5.53
p 3.0e-8
N 87,740
Meta-analysisLarge GWAS
European
About GRK6
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
View all GRK6 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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