rs2581066

This is a intron variant variant.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

glomerular filtration rate

Liu H et al. “Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease.” Nature Genetics 54(7):950-962 (2022)

Allele C

OR 7.56

p 4.0e-14

N 1,508,659

Large GWAS

multi-ancestry

serum creatinine amount

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)

Allele C

OR 0.01

p 2.0e-11

N 928,679

Large GWAS

multi-ancestry

kidney volume

Monteiro-Martins S et al. “Genetic screens of imaging-derived kidney volumes identify genes linked to kidney function.” Kidney International 109(2):365-378 (2026)

Allele G

OR 0.05

p 3.0e-9

N 38,816

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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