rs2584662

This is a intron variant variant.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Alzheimer disease, peptic ulcer disease, Peptic ulcer and gastro-oesophageal reflux disease (GORD) drug use measurement, gastroesophageal reflux disease

Adewuyi EO et al. “A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer's disease and gastrointestinal tract disorders.” Communications Biology 5(1):691 (2022)

Allele C

OR —

p 4.0e-9

N 911,585

Large GWAS

European

Alzheimer disease, gastroesophageal reflux disease

Adewuyi EO et al. “A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer's disease and gastrointestinal tract disorders.” Communications Biology 5(1):691 (2022)

Allele C

OR —

p 8.0e-9

N 787,859

Large GWAS

European

asthma, chronic obstructive pulmonary disease

John C et al. “Genetic Associations and Architecture of Asthma-COPD Overlap.” Chest 161(5):1155-1166 (2022)

Allele C

OR 0.92

p 2.0e-8

N 48,428

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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