rs2586970
This is a intron variant variant in the PPP4R3B gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
diastolic blood pressure
Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)
Allele A
OR 0.01
p 3.0e-16
N 1,212,859
Large GWAS
European
Plotnikov D et al. “High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study.” Investigative Ophthalmology & Visual Science 63(6):29 (2022)
Allele A
OR 0.16
p 2.0e-13
N 526,001
Large GWAS
European
About PPP4R3B
Predicted to enable protein phosphatase activator activity. Involved in regulation of double-strand break repair. Located in centrosome; chromatin; and nuclear speck. Part of protein phosphatase 4 complex. [provided by Alliance of Genome Resources, Jul 2025]
View all PPP4R3B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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