rs2617160
This variant is located in the KLRC4-KLRK1 gene.
▶Research that mentions this SNP (1)
▶Association of NKG2D genetic polymorphism with susceptibility to chronic hepatitis B in a Han Chinese populationAssociationN=500Juan Ma et al.(2010)· Journal of Medical Virology
This case-control association study of 500 Han Chinese patients analyzed genetic polymorphisms in NK cell receptor genes for association with chronic hepatitis B susceptibility. The TT genotype of rs2617160 in the NKG2D gene was independently associated with increased risk of chronic hepatitis B (P=0.044, OR=1.49, 95% CI=1.01-2.19), appearing more frequently in chronically infected patients (37.9%) than those who spontaneously cleared HBV (29.3%). Haplotype analysis of four NK receptor genes (KLRD1, KLRK1, KLRC4, KLRC1) showed no significant associations.
About KLRC4-KLRK1
This locus represents naturally occurring read-through transcription between the neighboring KLRC4 (killer cell lectin-like receptor subfamily C, member 4) and KLRK1 (killer cell lectin-like receptor subfamily K, member 1) genes on chromosome 12. The read-through transcript includes an alternate 5' exon and lacks a significant portion of the KLRC4 coding sequence, including the start codon, and it thus encodes the KLRK1 protein. [provided by RefSeq, Dec 2010]
View all KLRC4-KLRK1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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