rs2617167
This is a downstream gene variant variant in the KLRC4-KLRK1 gene.
▶Research that mentions this SNP (1)
▶Association between variants in inflammation and cancer‐associated genes and risk and survival of cholangiocarcinomaAssociationN=1,736Roongruedee Chaiteerakij et al.(2015)· Cancer Medicine
This candidate gene association study of 370 CCA cases and 740 controls identified initial associations between COX-2 variants rs2143417 (OR=1.52) and rs689466 (OR=1.36) and cholangiocarcinoma risk; however, these findings failed replication in an independent cohort of 212 cases and 424 controls (rs2143417 OR=1.04, rs689466 OR=1.08). No SNP variants showed significant associations with CCA survival, and NKG2D variants previously reported to be associated with CCA did not replicate.
About KLRC4-KLRK1
This locus represents naturally occurring read-through transcription between the neighboring KLRC4 (killer cell lectin-like receptor subfamily C, member 4) and KLRK1 (killer cell lectin-like receptor subfamily K, member 1) genes on chromosome 12. The read-through transcript includes an alternate 5' exon and lacks a significant portion of the KLRC4 coding sequence, including the start codon, and it thus encodes the KLRK1 protein. [provided by RefSeq, Dec 2010]
View all KLRC4-KLRK1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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