rs2645294

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GWAS Catalog Trait Associations (7)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

BMI-adjusted waist-hip ratio

Pulit SL et al. “Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.” Human Molecular Genetics 28(1):166-174 (2019)
Allele T
OR 0.03
p 1.0e-86
N 379,501
Meta-analysisLarge GWAS
European
Winkler TW et al. “The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.” Plos Genetics 11(10):e1005378 (2015)
Allele T
OR —
β 0.034
p 2.0e-25
N 252,375
Large GWAS
European
Justice AE et al. “Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.” Nature Communications 8:14977 (2017)
Allele T
OR 0.02
p 1.0e-8
N 149,672
Meta-analysisLarge GWAS
multi-ancestry
Shungin D et al. “New genetic loci link adipose and insulin biology to body fat distribution.” Nature 518(7538):187-196 (2015)
Allele T
OR 0.04
p 2.0e-14
N 143,480
Large GWAS
multi-ancestry

body height

Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)
Allele C
OR 0.01
p 2.0e-85
N 5,314,291
Large GWAS
European, Hispanic or Latin American, East Asian, African unspecified, South Asian

waist-hip ratio

Pulit SL et al. “Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.” Human Molecular Genetics 28(1):166-174 (2019)
Allele T
OR 0.02
p 1.0e-44
N 381,152
Meta-analysisLarge GWAS
European

BMI-adjusted waist-hip ratio, physical activity measurement

Graff M et al. “Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.” Plos Genetics 13(4):e1006528 (2017)
Allele T
OR 0.04
p 2.0e-14
N 156,653
Meta-analysisLarge GWAS
multi-ancestry

body mass index

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.02
p 2.0e-12
N 607,391
Major Consortium StudyLarge GWAS
multi-ancestry

smoking behavior, BMI-adjusted waist-hip ratio

Justice AE et al. “Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.” Nature Communications 8:14977 (2017)
Allele T
OR —
p 1.0e-9
N 191,661
Meta-analysisLarge GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Genome‐Wide Study of Subcutaneous and Visceral Adipose Tissue Reveals Novel Sex‐Specific Adiposity Loci in Mexican Americans
AssociationN=1,417Chuan Gao et al.(2018)· Obesity

This genome-wide association study (GWAS) in 1,417 Mexican Americans identified six loci with genome-wide significant associations with fat deposition phenotypes (visceral and subcutaneous adipose tissue). The strongest signal was rs2185405 in GLIS3 associated with visceral adipose tissue (P=1.98×10⁻⁸), with carriers of the minor allele showing 19.91 cm² less visceral fat. Sex-stratified analyses revealed SRFBP1 and SNX13 loci with male-specific associations, and SNP-sex interaction analyses identified significant variants in TMCC1, PAPPA2, and TBX15.

Traits studied:AdiposityBody mass indexInsulin resistanceSubcutaneous adipose tissueVisceral adipose tissueVisceral-subcutaneous ratio
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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