rs2650492

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body mass index

Winkler TW et al. “The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.” Plos Genetics 11(10):e1005378 (2015)
Allele A
OR —
β 0.024
p 7.0e-15
N 309,889
Large GWAS
European
Hoffmann TJ et al. “A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.” Genetics 210(2):499-515 (2018)
Allele A
OR —
β 0.021
p 2.0e-12
N 334,487
Large GWAS
multi-ancestry
Locke AE et al. “Genetic studies of body mass index yield new insights for obesity biology.” Nature 518(7538):197-206 (2015)
Allele A
OR 0.02
p 2.0e-9
N 238,944
Large GWAS
multi-ancestry

intelligence

Savage JE et al. “Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.” Nature Genetics 50(7):912-919 (2018)
Allele A
OR 7.66
p 2.0e-14
N 269,867
Meta-analysisLarge GWAS
European

waist circumference

Shungin D et al. “New genetic loci link adipose and insulin biology to body fat distribution.” Nature 518(7538):187-196 (2015)
Allele A
OR 0.03
p 2.0e-11
N 143,480
Large GWAS
multi-ancestry

physical activity measurement, body mass index

Graff M et al. “Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.” Plos Genetics 13(4):e1006528 (2017)
Allele A
OR 0.02
p 3.0e-8
N 161,368
Meta-analysisLarge GWAS
multi-ancestry

smoking behavior, body mass index

Justice AE et al. “Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.” Nature Communications 8:14977 (2017)
Allele A
OR 0.02
p 3.0e-8
N 196,760
Meta-analysisLarge GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Common variants in BDNF, FAIM2, FTO, MC4R, NEGR1, and SH2B1 show association with obesity‐related variables in Spanish Roma population
AssociationN=3,210Alaitz Poveda et al.(2014)· American Journal of Human Biology

This study performed fine mapping of the obesity-associated region chr16p11.2 by screening the coding regions of APOBR, SULT1A1, SULT1A2, and TUFM genes in 95 extremely obese children and adolescents. Two APOBR variants, rs180743 (p.Pro428Ala) and rs3833080 (p.Gly369_Asp370del9), showed significant association with obesity (p=0.002 and p=0.003 respectively) in case-control analysis of 1,873 obese cases versus 435 lean controls, with odds ratios of 1.27 and 1.25 per allele.

Traits studied:Body mass indexExtreme obesityObesity
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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