rs2657880

This is a downstream gene variant variant in the SPRYD4 gene.

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GWAS Catalog Trait Associations (8)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

tyrosine measurement

Abar L et al. “Unravelling genetic architecture of circulatory amino acid levels, and their effect on risk of complex disorders.” Nar Genomics and Bioinformatics 6(2):lqae046 (2024)

Allele G

OR 0.07

p 3.0e-42

N 117,944

Large GWAS

European

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele G

OR 0.07

p 3.0e-38

N 114,913

Large GWAS

European

Davyson E et al. “Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids.” Biological Psychiatry 94(8):630-639 (2023)

Allele G

OR 0.07

p 5.0e-29

N 88,207

Large GWAS

European

glutamine measurement

Li-Gao R et al. “Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism.” Diabetes 70(12):2932-2946 (2021)

Allele C

OR 0.34

p 3.0e-39

Large GWAS

Feofanova EV et al. “Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations.” Nature Communications 14(1):3111 (2023)

Allele C

OR 0.21

p 1.0e-31

N 11,216

Large GWAS

multi-ancestry

gamma-glutamylglutamine measurement

Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)

Allele C

OR 0.16

p 5.0e-35

N 14,296

Large GWAS

European

Hysi PG et al. “Metabolome Genome-Wide Association Study Identifies 74 Novel Genomic Regions Influencing Plasma Metabolites Levels.” Metabolites 12(1) (2022)

Allele C

OR 0.13

p 1.0e-11

N 8,809

Large GWAS

European

Feofanova EV et al. “Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations.” Nature Communications 14(1):3111 (2023)

Allele C

OR 0.20

p 4.0e-22

N 8,171

Large GWAS

multi-ancestry

lysine in blood amount

Lotta LA et al. “A cross-platform approach identifies genetic regulators of human metabolism and health.” Nature Genetics 53(1):54-64 (2021)

Allele C

OR 7.46

p 9.0e-14

N 30,982

Large GWAS

European

creatine kinase b-type measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele C

OR 0.05

p 3.0e-12

N 47,745

Large GWAS

European

triglyceride measurement

Hoffmann TJ et al. “A large electronic-health-record-based genome-wide study of serum lipids.” Nature Genetics 50(3):401-413 (2018)

Allele G

OR —

β 0.023

p 5.0e-10

N 283,251

Large GWAS

multi-ancestry

blood urea nitrogen amount

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.03

p 4.0e-22

N 599,920

Major Consortium StudyLarge GWAS

multi-ancestry

serum albumin amount

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.03

p 5.0e-14

N 372,962

Major Consortium StudyLarge GWAS

European

About SPRYD4

Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

View all SPRYD4 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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