rs2659051

This is a intron variant variant in the LOC105372441 gene.

▶

GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

prostate carcinoma

Conti DV et al. “Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.” Nature Genetics 53(1):65-75 (2021)
Allele G
OR 1.14
p 2.0e-8
N 177,526
Meta-analysisLarge GWAS
European
Sipeky C et al. “Novel prostate cancer susceptibility gene SP6 predisposes patients to aggressive disease.” Prostate Cancer and Prostatic Diseases 24(4):1158-1166 (2021)
Allele G
OR 0.72
p 6.0e-9
N 5,138
Large GWAS
European
▶

Research that mentions this SNP (1)

▶
Identification of a novel prostate cancer susceptibility variant in the KLK3 gene transcript
AssociationN=21,086Kote-Jarai Z. et al.(2011)· Human Genetics

Genome-wide association study identifying rs17632542 (Ile179Thr) in KLK3 gene as a strong prostate cancer susceptibility variant (combined P = 1.9 × 10⁻³⁴, OR = 0.66) across 10,405 cases and 10,681 controls. The variant was also associated with PSA levels and molecular dynamics modeling suggested it could alter protein stability or affect RNA splicing of KLK3.

Traits studied:Gleason scorePSA levelProstate cancer
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…