rs267607131
This is a variant in the TOP1 gene that changes a aspartate to an glycine.
▶ClinVar annotation
About TOP1
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008]
View all TOP1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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