rs269972

This is a regulatory region variant variant in the SLC14A2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

biological sex

Pirastu N et al. “Genetic analyses identify widespread sex-differential participation bias.” Nature Genetics 53(5):663-671 (2021)

Allele T

OR 0.02

p 1.0e-19

N 2,462,132

Large GWAS

European

About SLC14A2

The protein encoded by this gene belongs to the urea transporter family. In mammalian cells, urea is the chief end product of nitrogen catabolism, and plays an important role in the urinary concentration mechanism. This protein is expressed in the inner medulla of the kidney, and mediates rapid transepithelial urea transport across the inner medullary collecting duct. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]

View all SLC14A2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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