rs2731673

This is a regulatory region variant variant.

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GWAS Catalog Trait Associations (16)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

histidine measurement

Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele T
OR 0.07
p 4.0e-58
N 136,016
Large GWAS
multi-ancestry

inter-alpha-trypsin inhibitor heavy chain h4 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.09
p 1.0e-54
N 47,745
Large GWAS
European

alpha-2-antiplasmin measurement

Suhre K et al. “A genome-wide association study of mass spectrometry proteomics using a nanoparticle enrichment platform.” Nature Genetics 57(12):2987-2996 (2025)
Allele T
OR 0.45
p 7.0e-37
N 1,256
Large GWAS
multi-ancestry

transmembrane protein 87B measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele C
OR —
β 0.330
p 9.0e-34
N 3,301
Large GWAS
European

osteopontin measurement

Cheng Y et al. “Genetics of osteopontin in patients with chronic kidney disease: The German Chronic Kidney Disease study.” Plos Genetics 18(4):e1010139 (2022)
Allele C
OR 0.18
p 4.0e-25
N 4,897
Large GWAS
European

tRNA (guanine-N(7)-)-methyltransferase measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele C
OR 0.28
p 3.0e-23
N 3,301
Large GWAS
European

Kunitz-type protease inhibitor 2 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.06
p 2.0e-22
N 47,745
Large GWAS
European

UDP-glucuronic acid decarboxylase 1 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.06
p 4.0e-19
N 47,745
Large GWAS
European

neurexin-1 measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele C
OR —
β 0.240
p 6.0e-18
N 3,301
Large GWAS
European

vascular endothelial growth factor D measurement

Folkersen L et al. “Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals.” Nature Metabolism 2(10):1135-1148 (2020)
Allele T
OR —
β 0.082
p 5.0e-17
N 21,758
Large GWAS
European
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Research that mentions this SNP (1)

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An osteopontin (SPP1) polymorphism is associated with systemic lupus erythematosus
AssociationN=4,897Forton AC et al.(2002)· Human Mutation

Genome-wide association study of osteopontin (OPN) levels in 4,897 European chronic kidney disease patients identified 3 genome-wide significant loci (p < 5.0E-08). Two loci replicated in the Young Finns Study: rs10011284 upstream of SPP1 (encoding OPN; beta = -0.10, p = 8.59e-11) and rs4253311 in KLKB1 (encoding prekallikrein; beta = -0.14, p = 5.29e-20). A third locus rs2731673 near F12/GRK6 did not replicate. Rare variant testing identified SPP1 as significant (p = 2.5E-8), implicating OPN genetics in chronic kidney disease pathophysiology.

Traits studied:Chronic kidney diseaseOsteopontin serum levels
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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