rs2732685

This is a upstream gene variant variant in the LRRC37A gene.

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

left ventricular function

Tadros R et al. “Large-scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy.” Nature Genetics 57(3):530-538 (2025)
Allele C
OR 0.01
p 3.0e-17
N 36,083
Large GWAS
European, NR

left ventricular mass

Tadros R et al. “Large-scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy.” Nature Genetics 57(3):530-538 (2025)
Allele C
OR 0.35
p 2.0e-10
N 36,083
Large GWAS
European, NR

fatty acid amount

Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)
Allele T
OR —
p 8.0e-14
N 110,346
Large GWAS
European

About LRRC37A

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all LRRC37A variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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