rs2734842

This is a downstream gene variant variant in the DRD2 gene.

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Research that mentions this SNP (2)

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Converging evidence implicates the dopamine D3 receptor gene in vulnerability to schizophrenia
AssociationN=446Fuquan Zhang et al.(2011)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

A pharmacogenetic study of 446 schizophrenic patients (221 males, 225 females) from West Siberia investigating associations between 41 SNPs in dopaminergic genes and antipsychotic-induced hyperprolactinemia. The study found rs1799836 in MAOB gene associated with hyperprolactinemia in males (OR=0.748, p=0.048), and rs40184 and rs3863145 in SLC6A3 gene associated with hyperprolactinemia in the risperidone/paliperidone subgroup (OR=0.341, p=0.021 and OR=0.362, p=0.043, respectively), indicating protective effects.

Traits studied:Antipsychotic-induced hyperprolactinemiaSchizophrenia
PubMedDOIMetascience Observatory
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DRD3, but not COMT or DRD2, genotype affects executive functions in healthy and first‐episode psychosis adolescents
AssociationN=446Igor Bombin et al.(2008)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

A pharmacogenetic association study of 446 schizophrenia patients from West Siberia examined 41 SNPs in dopamine pathway genes (DRD1, DRD2, DRD3, DRD4, SLC6A3, MAOA, MAOB) for association with antipsychotic-induced hyperprolactinemia (HPRL). rs1799836 in MAOB showed significant protective association with HPRL in men (OR=0.748, p=0.048), while rs40184 (OR=0.341, p=0.021) and rs3863145 (OR=0.362, p=0.043) in SLC6A3 showed protective effects specifically in risperidone/paliperidone-treated patients.

Traits studied:Antipsychotic-induced hyperprolactinemiaHyperprolactinemiaSchizophrenia
PubMedDOIMetascience Observatory

About DRD2

This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]

View all DRD2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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