rs2737250

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

breast cancer, chronotype measurement

Wu X et al. “Using human genetics to understand the phenotypic association between chronotype and breast cancer.” Journal of Sleep Research 33(3):e13973 (2024)
Allele A
OR —
p 4.0e-15
N 696,907
Large GWAS
European
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Research that mentions this SNP (1)

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Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4
Meta-analysisN=41,996Ma RC et al.(2013)· Diabetologia

A genome-wide association study meta-analysis of 684 type 2 diabetes cases and 955 controls in Southern Han Chinese identified rs10229583 at 7q32 near PAX4 as a novel susceptibility locus. The risk allele (G) showed genome-wide significance in a combined analysis of 11,067 cases and 7,929 controls (p=2.6×10⁻⁸; OR [95% CI] 1.18 [1.11, 1.25]) and was consistently associated across East Asian populations (p=2.3×10⁻¹⁰; OR 1.14 [1.09, 1.19]) with evidence of replication in European descent populations (p=8.6×10⁻³). The variant was associated with elevated fasting plasma glucose, impaired beta cell function, and earlier age at diabetes diagnosis.

Traits studied:Age at diagnosisBeta cell functionFasting plasma glucoseType 2 diabetes
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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