rs27438

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

eosinophil percentage of leukocytes

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.06
p 6.0e-138
N 394,642
Large GWAS
European
Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)
Allele A
OR 0.05
p 5.0e-75
N 408,112
Large GWAS
European

eosinophil count

Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)
Allele A
OR 0.05
p 8.0e-63
N 408,112
Large GWAS
European
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Research that mentions this SNP (1)

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Genetic variation in the immunosuppression pathway genes and breast cancer susceptibility: a pooled analysis of 42,510 cases and 40,577 controls from the Breast Cancer Association Consortium
AssociationN=83,087Jieping Lei et al.(2016)· Human Genetics

A pooled analysis of 42,510 breast cancer cases and 40,577 controls from the Breast Cancer Association Consortium examined genetic variation in 3,595 SNPs across 133 immunosuppression pathway genes. The study identified SNP rs1905339 in STAT3 as significantly associated with increased breast cancer risk (OR 1.05, p=1.4×10⁻⁶). Gene-level analyses showed STAT3, IL5, and GM-CSF as novel susceptibility loci for breast cancer in women of European ancestry.

Traits studied:Breast cancerBreast cancer (ER-negative)Breast cancer (ER-positive)
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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