rs27740

▶

GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

level of sorting nexin-2 in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.09
p 3.0e-46
N 47,745
Large GWAS
European
▶

Research that mentions this SNP (1)

▶
HLA–E gene polymorphism associated with susceptibility to kawasaki disease and formation of coronary artery aneurysms
AssociationN=1,369Lin YJ et al.(2009)· Arthritis &amp; Rheumatism

This association study examined SNX24 genetic variants in 262 Kawasaki disease (KD) patients (76 with coronary artery aneurysm (CAA) and 186 without) compared to 1107 healthy controls. The SNX24 SNP rs28891 showed significant association with CAA formation (p=0.006), with CC and CT genotypes showing protective effects (OR=0.29, 95% CI=0.12-0.70 for CC genotype; OR=0.48, 95% CI=0.27-0.87 for CT genotype). Functional studies in endothelial cells demonstrated that SNX24 knockdown decreased proinflammatory cytokines IL-1β, IL-6, and IL-8.

Traits studied:Coronary artery aneurysmKawasaki disease
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…