rs2788032
This variant is located in the LRP8 gene.
▶Research that mentions this SNP (1)
▶Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women’s Health Initiative SHARe StudyAssociationN=11,687Digna R. Velez Edwards et al.(2013)· Human Genetics
A genome-wide gene-environment interaction study examined 8,203 African-American and 3,484 Hispanic postmenopausal women from the Women's Health Initiative SHARe GWAS for SNP interactions with lifestyle factors (smoking, diet, physical activity, alcohol) on BMI and waist-to-hip ratio. The strongest BMI gene-environment interaction across cohorts was rs10133840 with smoking (beta=-0.01, P=3.81×10^-7), and the strongest WHR interaction in African-Americans was rs9557704 (ITGBL1) with dietary energy intake (beta=-0.04, P=2.17×10^-7).
About LRP8
This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]
View all LRP8 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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