rs2834215

This is a intron variant variant in the IFNGR2 gene.

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Research that mentions this SNP (1)

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Pilot screening study of targeted genetic polymorphisms for association with seasonal influenza hospital admission
AssociationN=14,471Tonia C. Carter et al.(2018)· Journal of Medical Virology

This pilot screening study evaluated 32 SNPs in viral immune response genes for association with hospitalized seasonal influenza in adults of European ancestry using a discovery group (26 cases, 993 controls) and two validation groups (84 cases, 4,076 controls; 128 cases, 9,187 controls). The study failed to replicate the previously reported association between IFITM3 rs12252 and hospitalized influenza (P > 0.05), and a preliminary finding of association with SLFN13 rs8072510 (P = 0.0099 in discovery group) was not confirmed in validation groups.

Traits studied:Hospitalized seasonal influenzaInfluenza hospital admissionSevere influenza infection
PubMedDOIMetascience Observatory

About IFNGR2

This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008]

View all IFNGR2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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