rs2835267
This is a downstream gene variant variant in the CBR1-AS1 gene.
▶Research that mentions this SNP (1)
▶NNK reduction pathway gene polymorphisms and risk of lung cancerAssociationN=1,263Jennifer L. Modesto et al.(2015)· Molecular Carcinogenesis
Case-control study of 456 lung cancer cases and 807 controls investigating 53 tag-SNPs in genes encoding NNK-metabolizing enzymes (AKR1C1, AKR1C2, CBR1, HSD11B1). rs2835267 in CBR1 showed decreased lung cancer risk overall (OR: 0.76, p=0.048) and in high pack-year smokers with SCC (OR: 0.35, p=0.018); rs3787728 in CBR1 and rs4844880 in HSD11B1 also showed significant associations with specific histologies after multiple testing correction.
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…