rs28362691

This is a upstream gene variant variant in the AQP1 gene.

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Research that mentions this SNP (1)

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Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case–control samples
ReviewMartin Tesli et al.(2011)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

This review comprehensively summarizes the latest genetic studies on schizophrenia, including family studies (heritability ~80%), genome-wide association studies, epigenetic mechanisms, candidate gene investigations, and next-generation sequencing findings. Key GWAS findings identified 108 schizophrenia-associated loci including variants in MIR137 (rs1625579), TCF4 (rs12966547), CSMD1 (rs10503253), CACNA1C (rs4765905), ANK3 (rs10761482), and MHC region variants, with evidence for polygenetic inheritance involving both common SNPs and rare copy number variations.

Traits studied:Auditory steady-state responseAutism spectrum disorderBipolar disorderCognitive impairmentMental retardationSchizophreniaSchizophrenia endophenotypesSchizophrenia with general psychopathologic symptomsSchizophrenia with negative symptomsSchizophrenia with positive symptomsSensory processing disorderTreatment-resistant schizophreniaUnipolar depression
PubMedDOIMetascience Observatory

About AQP1

This gene encodes a small integral membrane protein with six bilayer spanning domains that functions as a water channel protein. This protein permits passive transport of water along an osmotic gradient. This gene is a possible candidate for disorders involving imbalance in ocular fluid movement. [provided by RefSeq, Aug 2016]

View all AQP1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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