rs28383314

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GWAS Catalog Trait Associations (54)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

eosinophil count

Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)

Allele C

OR 0.06

p 6.0e-199

N 474,237

Large GWAS

European

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.04

p 9.0e-101

N 442,919

Large GWAS

multi-ancestry

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele C

OR 0.05

p 6.0e-130

N 394,642

Large GWAS

European

Höglund J et al. “Gene-Based Variant Analysis of Whole-Exome Sequencing in Relation to Eosinophil Count.” Frontiers in Immunology 13:862255 (2022)

Allele C

OR 0.06

p 1.0e-49

N 365,954

Large GWAS

European

Kachuri L et al. “Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia.” American Journal of Human Genetics 108(10):1823-1835 (2021)

Allele C

OR —

p 6.0e-103

N 234,763

Large GWAS

European

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)

Allele C

OR 0.06

p 1.0e-60

N 172,275

Large GWAS

European

triglycerides in very small VLDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele C

OR 0.04

p 5.0e-87

N 450,015

Large GWAS

multi-ancestry

Davyson E et al. “Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids.” Biological Psychiatry 94(8):630-639 (2023)

Allele C

OR 0.05

p 7.0e-20

N 88,329

Large GWAS

European

triglycerides in small VLDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele C

OR 0.04

p 1.0e-84

N 450,015

Large GWAS

multi-ancestry

triglycerides in HDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele C

OR 0.04

p 3.0e-81

N 450,015

Large GWAS

multi-ancestry

Allele C

OR 0.04

p 9.0e-16

N 88,329

Large GWAS

European

triglycerides in medium HDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele C

OR 0.04

p 5.0e-81

N 450,015

Large GWAS

multi-ancestry

Allele C

OR 0.04

p 7.0e-16

N 88,329

Large GWAS

European

phospholipids in small HDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele C

OR 0.04

p 9.0e-78

N 450,015

Large GWAS

multi-ancestry

triglyceride measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele C

OR 0.03

p 3.0e-77

N 394,642

Large GWAS

European

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.03

p 4.0e-59

N 455,659

Large GWAS

multi-ancestry

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele C

OR 0.03

p 6.0e-66

N 450,015

Large GWAS

multi-ancestry

Richardson TG et al. “Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis.” Plos Medicine 17(3):e1003062 (2020)

Allele C

OR 0.04

p 4.0e-76

N 441,016

Large GWAS

European

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele C

OR 0.04

p 8.0e-24

N 115,082

Large GWAS

European

Allele C

OR 0.05

p 2.0e-20

N 88,329

Large GWAS

European

triglycerides in small HDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele C

OR 0.04

p 8.0e-77

N 450,015

Large GWAS

multi-ancestry

Allele C

OR 0.05

p 1.0e-20

N 88,329

Large GWAS

European

polyunsaturated fatty acids to monounsaturated fatty acids ratio

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele C

OR 0.04

p 8.0e-76

N 450,015

Large GWAS

multi-ancestry

Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)

Allele C

OR —

p 8.0e-19

N 239,268

Large GWAS

European

sclerosing cholangitis

Han Y et al. “Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis.” Nature Communications 14(1):1069 (2023)

Allele C

OR 0.20

p 2.0e-75

N 14,890

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

rs28383314

GWAS Catalog Trait Associations (54)

eosinophil count

triglycerides in very small VLDL measurement

triglycerides in small VLDL measurement

triglycerides in HDL measurement

triglycerides in medium HDL measurement

phospholipids in small HDL measurement

triglyceride measurement

triglycerides in small HDL measurement

polyunsaturated fatty acids to monounsaturated fatty acids ratio

sclerosing cholangitis

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