rs28407950

This is a regulatory region variant variant in the HLA-DQB1-AS1 gene.

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

asthma, Eczematoid dermatitis, allergic rhinitis

Johansson Å et al. “Genome-wide association analysis of 350 000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema.” Human Molecular Genetics 28(23):4022-4041 (2019)
Allele C
OR 1.12
p 7.0e-70
N 346,545
Major Consortium StudyLarge GWAS
European

childhood onset asthma

Pividori M et al. “Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.” The Lancet. Respiratory Medicine 7(6):509-522 (2019)
Allele C
OR 1.35
p 1.0e-59
N 327,670
Large GWAS
European

Eczematoid dermatitis, allergic rhinitis

Johansson Å et al. “Genome-wide association analysis of 350 000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema.” Human Molecular Genetics 28(23):4022-4041 (2019)
Allele C
OR 1.10
p 7.0e-45
N 323,807
Major Consortium StudyLarge GWAS
European

adult onset asthma

Pividori M et al. “Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.” The Lancet. Respiratory Medicine 7(6):509-522 (2019)
Allele C
OR 1.15
p 8.0e-31
N 339,801
Large GWAS
European

gut microbiome measurement

Moksnes MR et al. “The HUNT study identifies host genetic factors reproducibly associated with human gut microbiota composition.” Nature Genetics 58(3):530-539 (2026)
Allele T
OR —
p 4.0e-20
N 12,652
Large GWAS
European

Antihistamine use measurement

Wu Y et al. “Genome-wide association study of medication-use and associated disease in the UK Biobank.” Nature Communications 10(1):1891 (2019)
Allele T
OR 0.09
p 1.0e-10
N 151,636
Major Consortium StudyLarge GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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