rs28456

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GWAS Catalog Trait Associations (53)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

1-stearoyl-2-arachidonoyl-GPI (18:0/20:4) measurement

Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)
Allele A
OR 0.23
p 6.0e-95
N 14,296
Large GWAS
European

level of Phosphatidylinositol (18:0_20:3) in blood serum

Ottensmann L et al. “Genome-wide association analysis of plasma lipidome identifies 495 genetic associations.” Nature Communications 14(1):6934 (2023)
Allele G
OR 0.35
p 2.0e-88
N 6,784
Large GWAS
European
Tabassum R et al. “Lipidome- and Genome-Wide Study to Understand Sex Differences in Circulatory Lipids.” Journal of the American Heart Association 11(19):e027103 (2022)
Allele G
OR 0.34
p 6.0e-49
N 4,642
Large GWAS
European

esterified cholesterol measurement

Tabassum R et al. “Genetic architecture of human plasma lipidome and its link to cardiovascular disease.” Nature Communications 10(1):4329 (2019)
Allele G
OR 0.59
p 1.0e-77
N 2,045
Large GWAS
European

level of phosphatidylcholine

Tabassum R et al. “Genetic architecture of human plasma lipidome and its link to cardiovascular disease.” Nature Communications 10(1):4329 (2019)
Allele G
OR 0.58
p 5.0e-76
N 2,045
Large GWAS
European
Harshfield EL et al. “Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci.” Bmc Medicine 19(1):232 (2021)
Allele G
OR 0.04
p 1.0e-12
N 5,662
Large GWAS
South Asian

1-palmitoyl-2-arachidonoyl-GPI (16:0/20:4) measurement

Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)
Allele A
OR 0.19
p 2.0e-67
N 14,296
Large GWAS
European

lysophosphatidylcholine measurement

Tabassum R et al. “Genetic architecture of human plasma lipidome and its link to cardiovascular disease.” Nature Communications 10(1):4329 (2019)
Allele G
OR 0.46
p 5.0e-48
N 2,045
Large GWAS
European
Harshfield EL et al. “Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci.” Bmc Medicine 19(1):232 (2021)
Allele G
OR 0.06
p 1.0e-12
N 5,662
Large GWAS
South Asian

1-palmitoyl-2-stearoyl-GPC (16:0/18:0) measurement

Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)
Allele A
OR 0.14
p 2.0e-38
N 14,296
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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