rs2845885

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

BMI-adjusted waist-hip ratio

Lotta LA et al. “Association of Genetic Variants Related to Gluteofemoral vs Abdominal Fat Distribution With Type 2 Diabetes, Coronary Disease, and Cardiovascular Risk Factors.” Jama 320(24):2553-2563 (2018)

Allele C

OR 0.04

p 1.0e-31

N 660,648

Large GWAS

European

body mass index, high density lipoprotein cholesterol measurement

Huang LO et al. “Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities.” Nature Metabolism 3(2):228-243 (2021)

Allele T

OR —

p 8.0e-11

N 526,391

Large GWAS

multi-ancestry

triglyceride measurement, body mass index

Huang LO et al. “Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities.” Nature Metabolism 3(2):228-243 (2021)

Allele T

OR —

p 1.0e-10

N 517,085

Large GWAS

multi-ancestry

insulin measurement

Chen J et al. “The trans-ancestral genomic architecture of glycemic traits.” Nature Genetics 53(6):840-860 (2021)

Allele T

OR —

β 0.020

p 1.0e-8

N 151,013

Large GWAS

European

polyunsaturated fatty acids to total fatty acids percentage

Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)

Allele C

OR —

p 1.0e-8

N 110,346

Large GWAS

European

waist-hip ratio

Allele C

OR —

p 5.0e-8

N 663,598

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

rs2845885

GWAS Catalog Trait Associations (6)

BMI-adjusted waist-hip ratio

body mass index, high density lipoprotein cholesterol measurement

triglyceride measurement, body mass index

insulin measurement

polyunsaturated fatty acids to total fatty acids percentage

waist-hip ratio

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