rs28489187
This is a regulatory region variant variant in the DDAH1 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
asymmetrical dimethylarginine measurement, serum dimethylarginine amount
Seppälä I et al. “Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.” European Heart Journal 35(8):524-31 (2014)
Allele G
OR 0.37
p 1.0e-40
N 5,110
Large GWAS
European
serum dimethylarginine amount
Seppälä I et al. “Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.” European Heart Journal 35(8):524-31 (2014)
Allele G
OR 0.26
p 1.0e-20
N 5,110
Large GWAS
European
About DDAH1
This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. [provided by RefSeq, Jul 2008]
View all DDAH1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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