rs28520436

This is a intron variant variant in the PRR5L gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

atopic eczema

Budu-Aggrey A et al. “European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.” Nature Communications 14(1):6172 (2023)

Allele T

OR 1.18

p 5.0e-81

N 864,982

Meta-analysisLarge GWAS

European

Pasanen A et al. “Identifying Atopic Dermatitis Risk Loci in 1,094,060 Individuals with Subanalysis of Disease Severity and Onset.” The Journal of Investigative Dermatology 144(11):2417-2425 (2024)

Allele T

OR 0.17

p 5.0e-20

N 1,094,060

Large GWAS

multi-ancestry

About PRR5L

Enables ubiquitin protein ligase binding activity. Involved in several processes, including TORC2 signaling; regulation of fibroblast migration; and regulation of primary metabolic process. Part of TORC2 complex. [provided by Alliance of Genome Resources, Jul 2025]

View all PRR5L variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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