rs28521337

This is a intron variant variant in the NTRK3 gene.

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Research that mentions this SNP (1)

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Analysis of a polymorphic microRNA target site in the purinergic receptor P2RX7 gene
ReviewOmar Abdul Rahman et al.(2010)· ELECTROPHORESIS

This narrative review examines the role of microRNAs (miRNAs) in neuropsychiatric disorders including schizophrenia, bipolar disorder, major depression, Alzheimer's disease, and Parkinson's disease. The paper synthesizes studies on miRNA expression alterations in peripheral tissues and genetic variants in miRNA-related genes (SNPs in miRNAs, miRNA target genes, and miRNA processing genes), highlighting the potential of miRNAs as biomarkers for diagnosis and prognosis of brain diseases.

Traits studied:Alzheimer's diseaseAnxiety disorderBipolar disorderFrontotemporal lobar degenerationMajor depressionMild cognitive impairmentObsessive-compulsive disorderPanic disorderParkinson's diseaseSchizophreniaTourette's syndrome
PubMedDOIMetascience Observatory

About NTRK3

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

View all NTRK3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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