rs2857151

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

mucocutaneous lymph node syndrome

Onouchi Y et al. “A genome-wide association study identifies three new risk loci for Kawasaki disease.” Nature Genetics 44(5):517-21 (2012)
Allele G
OR 1.47
p 5.0e-11
N 3,807
Large GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Combined analysis of genome-wide-linked susceptibility loci to Kawasaki disease in Han Chinese
AssociationN=1,173Yuanlong Yan et al.(2013)· Human Genetics

Association study of 6 GWAS-identified susceptibility SNPs with Kawasaki disease in 358 Han Chinese patients and 815 controls. Risk alleles of rs1801274 (FCGR2A, OR=1.33) and rs2254546 (BLK, OR=1.44) showed significant associations. Meta-analyses confirmed significant effects for rs113420705 (CASP3, OR=1.40), rs2857151 (HLA, OR=1.41), and rs4813003 (CD40, OR=1.37). A 3-locus combination (rs113420705 + rs2857151 + rs4813003) showed the strongest association (OR=2.15, P=0.0003), suggesting additive genetic effects on disease susceptibility and coronary artery lesion formation.

Traits studied:Coronary artery lesionsKawasaki disease
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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