rs2858331
This is a upstream gene variant variant.
▶GWAS Catalog Trait Associations (7)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (7)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
level of leucine-rich repeat-containing protein 25 in blood
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.06
p 3.0e-38
N 47,745
Large GWAS
European
anti-SARS-CoV-2 IgG measurement, response to COVID-19 vaccine
Bian S et al. “Genetic determinants of IgG antibody response to COVID-19 vaccination.” American Journal of Human Genetics 111(1):181-199 (2024)
Allele G
OR 1.19
p 8.0e-26
N 54,066
Large GWAS
European
blood protein amount
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.01
p 2.0e-17
N 47,745
Large GWAS
European
omega-6 polyunsaturated fatty acid measurement
Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)
Allele G
OR —
p 7.0e-14
N 110,346
Large GWAS
European
Alzheimer disease, peptic ulcer disease, Peptic ulcer and gastro-oesophageal reflux disease (GORD) drug use measurement, gastroesophageal reflux disease
Adewuyi EO et al. “A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer's disease and gastrointestinal tract disorders.” Communications Biology 5(1):691 (2022)
Allele G
OR —
p 3.0e-10
N 911,585
Large GWAS
European
serum IgE amount
Granada M et al. “A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study.” The Journal of Allergy and Clinical Immunology 129(3):840-845.e21 (2012)
Allele G
OR —
β 0.040
p 1.0e-8
N 6,819
CohortLarge GWAS
European
Henoch-Schoenlein purpura
Koskela M et al. “HLA-DQ and HLA-DRB1 alleles associated with Henoch-Schönlein purpura nephritis in Finnish pediatric population: a genome-wide association study.” Pediatric Nephrology (berlin, Germany) 36(8):2311-2318 (2021)
Allele G
OR 3.82
p 4.0e-8
N 18,803
Large GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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