rs28832309

This is a intergenic variant variant.

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

HDL cholesterol change measurement, physical activity

Kilpeläinen TO et al. “Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.” Nature Communications 10(1):376 (2019)

Allele C

OR —

p 2.0e-21

N 120,979

Large GWAS

multi-ancestry

depressive symptom measurement, non-high density lipoprotein cholesterol measurement

Bentley AR et al. “Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.” Translational Psychiatry 15(1):207 (2025)

Allele C

OR —

β 0.006

p 3.0e-20

N 133,157

Large GWAS

multi-ancestry

metabolite measurement

Tahir UA et al. “Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals.” Nature Communications 13(1):4923 (2022)

Allele C

OR 0.40

p 2.0e-15

N 2,466

Large GWAS

multi-ancestry

C40:7 phosphatidylethanolamine plasmalogen measurement

Allele C

OR 0.35

p 2.0e-12

N 2,466

Large GWAS

multi-ancestry

eosinophil count

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.07

p 5.0e-13

N 447,598

Major Consortium StudyLarge GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

rs28832309

GWAS Catalog Trait Associations (5)

HDL cholesterol change measurement, physical activity

depressive symptom measurement, non-high density lipoprotein cholesterol measurement

metabolite measurement

C40:7 phosphatidylethanolamine plasmalogen measurement

eosinophil count

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