rs2891698

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GWAS Catalog Trait Associations (7)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Barrett's esophagus

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.10
p 6.0e-19
N 446,841
Major Consortium StudyLarge GWAS
European

gastroesophageal reflux disease

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.03
p 5.0e-14
N 412,728
Major Consortium StudyLarge GWAS
European

diaphragmatic hernia

Campbell M et al. “Identification of 14 novel susceptibility loci for diaphragmatic hernia development and their biological and clinical implications: results from the UK Biobank.” Surgical Endoscopy 36(10):7647-7651 (2022)
Allele G
OR —
p 3.0e-13
N 275,546
Major Consortium StudyLarge GWAS

drug use measurement, gastroesophageal reflux disease

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.04
p 4.0e-12
N 404,034
Major Consortium StudyLarge GWAS
multi-ancestry

Hiatus hernia

Ahmed WU et al. “Shared genetic architecture of hernias: A genome-wide association study with multivariable meta-analysis of multiple hernia phenotypes.” Plos One 17(12):e0272261 (2022)
Allele G
OR 1.06
p 4.0e-10
N 193,788
Meta-analysisLarge GWAS
European

Hernia

Ahmed WU et al. “Shared genetic architecture of hernias: A genome-wide association study with multivariable meta-analysis of multiple hernia phenotypes.” Plos One 17(12):e0272261 (2022)
Allele G
OR —
p 1.0e-9
N 344,508
Meta-analysisLarge GWAS
European

esophageal disease

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.03
p 2.0e-14
N 413,308
Major Consortium StudyLarge GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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