rs2916702

This candidate gene study investigated 9 genes in angiopoietin and pericyte pathways in 149 patients with colorectal liver metastases treated with neoadjuvant/adjuvant fluoropyrimidine-based chemotherapy plus bevacizumab and liver resection. Key findings: RALBP1 rs329007 associated with shorter recurrence-free survival (HR 1.99, p=0.002) and higher radiological response (94% vs 78%); PDGFB rs1800818 associated with worse 3-year overall survival (53% vs 78%, p=0.048); ANGPT2 rs2916702 and rs2442631 predicted probability of cure.

This case-control study of 1,529 critically ill patients (449 ARDS cases, 1,080 controls) examined genetic variants in the angiopoietin-2 (ANGPT2) gene and their association with acute respiratory distress syndrome (ARDS) risk. Nine tagging SNPs spanning the entire ANGPT2 gene were genotyped and analyzed using logistic regression. The variant T allele of rs2515475 was significantly associated with increased ARDS risk overall (OR adjusted = 1.28, p = 0.042) and more strongly in subjects with extrapulmonary injuries (OR adjusted = 1.79, p = 0.004). A haplotype containing the T alleles of rs2515475 and rs2959811 was also significantly associated with ARDS risk (OR = 1.42, p = 0.009; OR = 1.90 in extrapulmonary injury patients, p = 0.004).