rs2918307

This variant is located in the NFILZ gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

atopic eczema

Chen Y et al. “Genome-Wide Integration of Genetic and Genomic Studies of Atopic Dermatitis: Insights into Genetic Architecture and Pathogenesis.” The Journal of Investigative Dermatology 142(11):2958-2967.e8 (2022)

Allele A

OR 0.09

p 7.0e-14

N 837,496

Large GWAS

multi-ancestry

Paternoster L et al. “Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.” Nature Genetics 47(12):1449-1456 (2015)

Allele A

OR 1.12

p 5.0e-12

N 116,863

Large GWAS

multi-ancestry

About NFILZ

Predicted to enable DNA binding activity and DNA-binding transcription factor activity. Predicted to be involved in circadian rhythm and regulation of DNA-templated transcription. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

View all NFILZ variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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