rs2932974

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

thalamus volume

Elvsåshagen T et al. “The genetic architecture of the human thalamus and its overlap with ten common brain disorders.” Nature Communications 12(1):2909 (2021)
Allele G
OR 0.06
p 8.0e-10
N 30,114
Large GWAS
European
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Research that mentions this SNP (1)

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Common variation at PPARGC1A/B and change in body composition and metabolic traits following preventive interventions: the Diabetes Prevention Program
AssociationN=3,234Paul W. Franks et al.(2014)· Diabetologia

This study examined associations between PPARGC1A and PPARGC1B variants and cardiometabolic traits in 3,234 participants of the Diabetes Prevention Program. PPARGC1A variation was strongly associated with baseline triacylglycerol (p=2.9×10⁻³⁰), BMI (p=2.0×10⁻⁵), and changes in these traits at 1 year. The Gly482Ser variant (rs8192678) was associated with subcutaneous adiposity and insulin resistance, while rs2970852 modified metformin's effect on triacylglycerols (p=0.04).

Traits studied:Body mass index (BMI)Glucose concentrationsInsulin resistanceSubcutaneous adiposityTriacylglycerol concentrationsType 2 diabetesVisceral adiposityWaist circumference
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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