rs2946834

This variant is located in the LINC02456 gene.

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Research that mentions this SNP (2)

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Association of a common genetic variant of the IGF-1 gene with event-free survival in patients with HER2-positive breast cancer
AssociationN=161Axel Muendlein et al.(2013)· Journal of Cancer Research and Clinical Oncology

This association study examined the relationship between five IGF-1 gene SNPs and event-free survival in 161 HER2-positive breast cancer patients. The rare allele of rs2946834 was significantly associated with poor clinical outcome (HR = 4.02 [1.36-11.90]; p = 0.012 in multivariate analysis), while the other four SNPs studied showed no significant associations with survival.

Traits studied:HER2-positive breast cancerbreast cancer prognosiscolorectal cancerevent-free survivaloverall survival
PubMedDOIMetascience Observatory
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IGF1, IGFBP1, and IGFBP3 genes and mammographic density: The Multiethnic Cohort
AssociationN=819Martijn Verheus et al.(2010)· International Journal of Cancer

This study investigated the association between common genetic variation in IGF1, IGFBP1, and IGFBP3 genes and mammographic density in 819 women from the Multiethnic Cohort. Only weak evidence was found for associations: rs35767 (IGF1, p=0.03) was associated with 3.2% lower mammographic density, rs35539615 (IGFBP1, p=0.05) with higher density, and rs2453839 (IGFBP3, p=0.01) with lower density. Ethnicity significantly modified the associations for IGFBP3 variants.

Traits studied:Mammographic density
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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