rs294777

This is a regulatory region variant variant in the UGT2B10 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

cotinine glucuronidation measurement

Patel YM et al. “The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations.” Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 24(1):119-27 (2015)

Allele A

OR 0.19

p 6.0e-48

N 2,239

Large GWAS

multi-ancestry

About UGT2B10

Predicted to enable UDP-glycosyltransferase activity. Predicted to be involved in estrogen metabolic process. Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all UGT2B10 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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