rs2953475

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

lymphocyte count

Kachuri L et al. “Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia.” American Journal of Human Genetics 108(10):1823-1835 (2021)
Allele C
OR —
p 1.0e-38
N 234,778
Large GWAS
European

neutrophil-to-lymphocyte ratio

Kachuri L et al. “Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia.” American Journal of Human Genetics 108(10):1823-1835 (2021)
Allele C
OR —
p 6.0e-30
N 234,502
Large GWAS
European
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Research that mentions this SNP (1)

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Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility
AssociationN=7,792Rebecca L. Zuvich et al.(2010)· Human Genetics

This pathway-based association study identified genetic variations in the IL7RA/IL7 signaling pathway that increase multiple sclerosis susceptibility. Two novel genes replicated in an independent dataset: IL7 (rs2587156, p=8.29×10−6, OR=1.35) and SOCS1 (rs441349, p=3.48×10−7, OR=1.25). Additional candidate genes with suggestive evidence include PRKCE (p=3.47×10−4), BCL2 (p=4.32×10−4), and TYK2. The study analyzed 2,961 MS cases and controls in discovery, with 4,831 samples in replication, examining 7,865 SNPs across 73 genes in this biologically-relevant immune pathway.

Traits studied:Multiple sclerosis
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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